Lymphohistiocytoid Mesothelioma: Causes and Treatment

Mesothelioma is a rare form of cancer that develops in the lining of organs, most often in the lungs. Lymphohistiocytoid mesothelioma is an even rarer subtype of this disease, accounting for only a small percentage of mesothelioma cases. This type of mesothelioma is especially challenging to diagnose and treat due to its unique characteristics. In this article, we will delve into the causes and treatment options for lymphohistiocytoid mesothelioma.


Like other types of mesothelioma, lymphohistiocytoid mesothelioma is caused by exposure to asbestos. Asbestos is a group of minerals that were commonly used in construction materials, such as insulation, roofing, and flooring, due to their fire-resistant and durable properties. When asbestos fibers are inhaled, they can become trapped in the lining of the lungs, causing irritation and scarring over time. This can lead to the development of mesothelioma and other respiratory diseases.

However, unlike other types of mesothelioma, lymphohistiocytoid mesothelioma occurs more frequently in individuals who have not had significant exposure to asbestos. It is thought that this subtype of mesothelioma may also be caused by other environmental factors or genetic predisposition, but the exact mechanisms are not yet fully understood.


Treatment options for lymphohistiocytoid mesothelioma are similar to those for other types of mesothelioma. The primary goal of treatment is to slow the progression of the disease and manage symptoms. Unfortunately, lymphohistiocytoid mesothelioma is often diagnosed at a later stage, making it more challenging to treat and manage.

Some common treatment options for lymphohistiocytoid mesothelioma include:

  • Surgery: Surgical removal of the affected tissue may be an option for some patients, depending on the location and stage of the cancer.
  • Chemotherapy: Chemotherapy involves the use of drugs to kill cancer cells. This treatment can be given orally or intravenously and is often used in combination with other treatments.
  • Radiation therapy: Radiation therapy uses high-energy X-rays to kill cancer cells. It can be used to shrink tumors or destroy any remaining cancer cells after surgery.
  • Immunotherapy: Immunotherapy is a newer treatment option that involves using the body's immune system to fight off cancer cells. This treatment is often used in combination with other treatments.

It is important to note that the effectiveness of these treatments can vary depending on the individual's overall health, the stage of the cancer, and other factors. For this reason, it is vital to work closely with a medical team experienced in mesothelioma treatment and to discuss all available options.


Lymphohistiocytoid mesothelioma is a rare and challenging form of cancer. It is caused primarily by exposure to asbestos, although other factors may also play a role. While treatment options are available, there is no cure for this disease. If you or a loved one has been diagnosed with lymphohistiocytoid mesothelioma, it is important to seek out medical care from experienced professionals and explore all available treatment options.