Localized Mesothelioma: Diagnosis and Treatment

Mesothelioma is a rare and aggressive form of cancer that affects the lining of the lungs, abdomen and, rarely, the heart. It is often caused by exposure to asbestos, a naturally occurring mineral that was widely used in construction and manufacturing during the 20th century. Mesothelioma can take decades to develop and symptoms may not appear until the disease is in an advanced stage. While mesothelioma is a serious disease, there is some good news for patients with a type called localized mesothelioma. This form of the disease is less common than the more aggressive and advanced form and is limited to a single area or organ. For patients with localized mesothelioma, the prognosis can be significantly improved with prompt diagnosis and treatment.

Diagnosing Localized Mesothelioma

The first step in diagnosing mesothelioma is often a physical exam and a review of the patient's medical history. From there, doctors may order imaging tests, such as chest x-rays, CT scans, or MRIs, to get a better view of any abnormal masses or fluid buildup. If there is a suspicious area seen on imaging, doctors may proceed to a biopsy, which involves removing a small piece of tissue for analysis under a microscope. Depending on the location of the suspected mesothelioma, a variety of different biopsy techniques may be used. For mesothelioma affecting the lungs, a procedure called a thoracoscopy may be used, which involves making a small incision near the ribs to insert a tiny camera and tools for tissue removal. For mesothelioma in the abdomen, a laparoscopy may be used, which also involves a small incision to insert a camera and tools. In rare cases, if the pericardium, the lining around the heart, is affected, a biopsy may require open heart surgery.

Treating Localized Mesothelioma

The best treatment for localized mesothelioma will depend on the location and extent of the disease, as well as the patient's overall health and preferences. While treatment options for more advanced stages of mesothelioma may be limited, there may be more options available for patients with localized mesothelioma. Surgery is often the primary treatment for localized mesothelioma. The goal of surgery is to remove all of the cancerous tissue while preserving as much healthy tissue as possible. In some cases, this may be accomplished with a minimally invasive procedure, such as a thoracoscopy or laparoscopy. In other cases, more extensive surgery may be required, such as a thoracotomy, which involves making a larger incision in the chest or abdomen. In some cases, surgery may be followed by chemotherapy or radiation therapy to help ensure that any remaining cancerous cells are destroyed. Chemotherapy involves the use of drugs to kill cancer cells, while radiation therapy uses high-energy radiation to target and destroy cancer cells. In addition to these more traditional treatments, there are also some newer therapies being developed for mesothelioma. Immunotherapy, for example, involves using drugs to help boost the body's own immune system to fight the cancer. Clinical trials are also underway for other innovative treatments, including gene therapy and targeted therapy.

Managing Symptomatic Relief

In addition to treating the mesothelioma itself, doctors may also recommend other strategies to help manage symptoms and improve overall quality of life. This might include:
  • Pain management: Prescription painkillers or other pain medications may be prescribed to help alleviate discomfort.
  • Supportive care: This might involve working with a physical therapist to maintain strength and flexibility or working with a nutritionist to ensure that patients are getting the nutrients they need.
  • Palliative care: For patients with more advanced mesothelioma or those who may not be candidates for surgery or other aggressive treatment, palliative care may focus on managing symptoms and providing comfort rather than attempting to cure the disease.


Localized mesothelioma is a rare form of the disease that is limited to a single area or organ. While it is still a serious condition, patients with localized mesothelioma may have more treatment options available to them than those with more advanced stages of the disease. Early diagnosis is key for ensuring the best possible outcomes, so it's important to seek prompt medical attention if you have any symptoms that may be related to mesothelioma. By working with a team of experienced doctors and healthcare professionals, you can get the help you need to fight this disease and improve your quality of life.