Stage Peritoneal Mesothelioma: What You Need to Know

What is Peritoneal Mesothelioma?

Peritoneal mesothelioma is a rare and aggressive cancer that affects the peritoneum, which is the lining of the abdominal cavity. It is caused by exposure to asbestos fibers, which can become embedded in the peritoneum and cause cells to become cancerous. Peritoneal mesothelioma is one of several types of mesothelioma cancer, which also include pleural mesothelioma (which affects the lungs) and pericardial mesothelioma (which affects the heart).

Peritoneal mesothelioma is often difficult to diagnose, as symptoms may not appear until the cancer has progressed to later stages. Common symptoms include abdominal pain, bloating, nausea, and difficulty eating. As with other types of mesothelioma, peritoneal mesothelioma has a poor prognosis, with most patients surviving for less than a year after diagnosis.

Stages of Peritoneal Mesothelioma

Peritoneal mesothelioma is divided into four stages, each of which represents a different level of cancer progression. These stages are based on factors such as tumor size, location, and spread to other parts of the body. Knowing the stage of peritoneal mesothelioma is important in determining the best treatment options and overall prognosis for the patient.

Stage 1

In Stage 1, the cancer is localized to the peritoneum and has not spread to other organs or tissues. Tumors are relatively small and can be surgically removed with a high rate of success. Patients in Stage 1 typically have the best prognosis, with a 5-year survival rate of 50% or higher.

Stage 2

In Stage 2, the cancer has spread beyond the peritoneum and may affect nearby organs such as the liver or spleen. Tumors are larger than in Stage 1, but can still be surgically removed in some cases. Prognosis varies depending on the extent of spread and the effectiveness of treatment, with a 5-year survival rate of around 20-30%.

Stage 3

In Stage 3, the cancer has spread to multiple organs and tissues in the abdomen, making it difficult to remove surgically. Treatment options may include chemotherapy or radiation therapy, but the prognosis is poor, with a 5-year survival rate of less than 10%.

Stage 4

In Stage 4, the cancer has metastasized (spread) to other parts of the body such as the lungs or lymph nodes. Treatment options are limited, and the prognosis is very poor, with most patients surviving for only a few months after diagnosis.

Treatment Options for Peritoneal Mesothelioma

Treatment for peritoneal mesothelioma typically involves a combination of surgery, chemotherapy, and radiation therapy. The specific treatment plan will depend on factors such as the stage of the cancer, the patient's overall health, and the extent of spread.


Surgery is often the first line of treatment for peritoneal mesothelioma. Depending on the stage and location of the cancer, surgery may involve removing all or part of the peritoneum, as well as any affected organs such as the spleen or parts of the intestine. In some cases, surgery may be done in combination with chemotherapy or radiation therapy to improve the chances of success.


Chemotherapy involves the use of drugs to kill cancer cells. For peritoneal mesothelioma, chemotherapy may be given directly into the abdomen (intraperitoneal chemotherapy) to target the cancer cells more effectively. Chemotherapy may also be given in combination with surgery or radiation therapy to improve the chances of success.

Radiation Therapy

Radiation therapy involves the use of high-energy radiation to kill cancer cells. For peritoneal mesothelioma, radiation therapy may be used to shrink tumors before surgery, or to kill remaining cancer cells after surgery. Radiation therapy may also be used in combination with chemotherapy for more advanced cases.

Alternative and Complementary Therapies

Some patients with peritoneal mesothelioma may choose to pursue alternative or complementary therapies in addition to conventional treatment. These may include things like acupuncture, massage therapy, nutritional supplements, and herbal remedies. While these therapies may help improve quality of life and comfort, there is little scientific evidence to support their effectiveness in treating cancer.

Living with Peritoneal Mesothelioma

Living with peritoneal mesothelioma can be challenging, both physically and emotionally. Patients may experience a range of symptoms and side effects from treatment, as well as emotional stress and anxiety related to their diagnosis. It's important to seek out support from family, friends, and healthcare professionals to help manage these challenges.

Support Groups

Support groups can be a valuable resource for patients with peritoneal mesothelioma. These groups provide a safe and supportive environment to share experiences and connect with others who are going through similar challenges. Support groups may be available in-person or online, and may be led by a healthcare professional or by other patients and caregivers.

Physical Therapy

Physical therapy can be helpful for patients with peritoneal mesothelioma who are experiencing pain, weakness, or loss of function. A physical therapist can help develop an exercise program tailored to the patient's individual needs and abilities, which can help improve strength, flexibility, and overall physical function.

Nutrition and Diet

A healthy diet and good nutrition are important for patients with peritoneal mesothelioma, as they can help improve overall health and boost the immune system. Patients should aim to eat a balanced diet rich in fruits, vegetables, whole grains, and lean protein sources. Patients may also benefit from working with a registered dietitian to develop a personalized nutrition plan.


Peritoneal mesothelioma is a rare and aggressive cancer that can be difficult to diagnose and treat. Treatment typically involves a combination of surgery, chemotherapy, and radiation therapy, with the specific plan tailored to the individual patient. Living with peritoneal mesothelioma can be challenging, but with the support of healthcare professionals, family, and friends, patients can manage their symptoms and improve their quality of life.